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Toxicol Pathol. 2015 Dec;43(8):1166-71. doi: 10.1177/0192623315595883. Epub 2015 Jul 27.

Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists.

Author information

1
WIL Research, Hillsborough, North Carolina, USA amera.remick@wilresearch.com.
2
Developmental and Reproductive Toxicology Group, Toxicology Branch, National Toxicology Program (NTP) Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
3
Reproductive Endocrinology Group, National Toxicology Program Laboratory (NTPL), and NTP Pathology Group, Cellular & Molecular Pathology Branch, NTP Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
4
Experimental Pathology Laboratories, Inc., Durham, North Carolina, USA.
5
Molecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

Abstract

The Society of Toxicologic Pathology (STP) Education Committee and the STP Reproductive Special Interest Group held a North Carolina regional meeting entitled, "Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists" on March 13, 2015, at the National Institute of Environmental Health Sciences/National Toxicology Program in Research Triangle Park, North Carolina. The purpose of this regional meeting was to familiarize attendees with the topic of juvenile toxicity testing and discuss its relevance to clinical pediatric medicine, regulatory perspectives, challenges of appropriate study design confronted by toxicologists, and challenges of histopathologic examination and interpretation of juvenile tissues faced by pathologists. The 1-day meeting was a success with over 60 attendees representing industry, government, research organizations, and academia.

KEYWORDS:

developmental pathology; drug development; pediatrics; pharmaceutical development/products; preclinical safety assessment/risk management; toxicologic pathology

PMID:
26220944
PMCID:
PMC4670269
DOI:
10.1177/0192623315595883
[Indexed for MEDLINE]
Free PMC Article

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