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J Gerontol A Biol Sci Med Sci. 2016 May;71(5):593-600. doi: 10.1093/gerona/glv063. Epub 2015 Jul 28.

Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms.

Author information

1
Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, Spain.
2
Department of Periodontology, Dental School, University of Sevilla, Spain.
3
Dip. Scienze Cliniche Specialistiche ed Odontostomatologiche, Università Politecnica delle Marche, Ancona, Italia.
4
Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, Spain.
5
Department of Citología e Histología Normal y Patológica, Universidad de Sevilla, Spain.
6
Department of Pathology, Complejo Hospitalario de Jaén, Spain.
7
Dip. Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italia.
8
Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, Spain. jlquiles@ugr.es.

Abstract

An age-dependent model of the periodontium was reproduced to evaluate the effect of life-long feeding on a low coenzyme Q10 dosage in n-6, n-3 polyunsaturated fatty acid or monounsaturated fatty acid-based diets on periodontal tissues of young and old rats. Results shown that exacerbated age-related alveolar bone loss previously associated to n-6 polyunsaturated fatty acid diet was attenuated by coenzyme Q10 Gene expression analysis suggests that involved mechanisms might be related to a restored capacity of mitochondria to adapt to aging in gingival cells from rats fed on n-6 polyunsaturated fatty acid. In particular, this could be due to an age-related increase of the rate of mitochondrial biogenesis and a better oxidative and respiratory balance in these animals. From the nutritional and clinical point of view, it is noteworthy that supplementation with coenzyme Q10 could counteract the negative effects of n-6 polyunsaturated fatty acid on alveolar bone loss (a major feature of periodontitis) associated to age.

KEYWORDS:

Biogenesis; Electron transport chain; Fish oil; Sunflower oil; Virgin olive oil

PMID:
26219851
DOI:
10.1093/gerona/glv063
[Indexed for MEDLINE]

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