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Eye Contact Lens. 2016 May;42(3):158-62. doi: 10.1097/ICL.0000000000000180.

Risk Factors for Contact Lens-Related Microbial Keratitis: A Case-Control Multicenter Study.

Author information

1
Service d'Ophtalmologie (A.S., T.B.), Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France; and Service de Méthodologie et Biostatistiques (N.M.), Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Abstract

PURPOSE:

The most feared complication of contact lens (CL) wear is microbial keratitis (MK), even though its incidence remains low. This study aimed to identify the risk factors of CL-related MK in a large, prospective, multicenter case-control study.

METHODS:

A multicenter case-control study was designed. The CL-related MK subpopulation (Case) was compared with healthy CL wearers (Control) using a 52-item anonymous questionnaire designed to determine subject demographics and lens wear history. Univariate and multivariate logistic regression analyses were performed to compare both groups.

RESULTS:

The study enrolled 499 cases and 508 controls. The risk factors associated with the greatest increased odds of CL-related MK were as follows: using disinfecting solution more than 3 months (odds ratio [OR]=1.94), cosmetic CL wear and use of multipurpose disinfection solution (1.37 each), overnight wear, and soft lens use (OR=1.24 each). The protective factors associated with the greatest reduction in OR were fitting by an ophthalmologist (OR=0.73) and hyperopia versus myopia (OR=0.75).

CONCLUSIONS:

The infectious determinants were linked to the type of lenses, hygiene routine, CL handling, disinfecting solution, and storage case. This study aimed to highlight the increasingly CL-related MK, which likely occurs because of lack of patient information regarding basic rules of hygiene and CL care and handling.

PMID:
26219076
DOI:
10.1097/ICL.0000000000000180
[Indexed for MEDLINE]

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