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World J Gastroenterol. 2015 Jul 21;21(27):8284-92. doi: 10.3748/wjg.v21.i27.8284.

MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity.

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Michael Hollis, Lakshmi Shankar Chaturvedi, Sahil Gambhir, Dinesh Vyas, Department of Surgery, College of Human Medicine, Michigan State University, East Lansing, MI 48912, United States.


Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific miRNA may display the effects of a tumor suppressor or oncogene. Altered miRNA expression is found in colorectal cancer (CRC) and patterns of miRNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum miRNA and fecal miRNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of miRNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC.


Colorectal cancer; Diagnostic; Expression; Fecal microRNA; MicroRNA; Prognostic; Serum microRNA; Therapeutic

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