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J Oral Pathol Med. 2016 Mar;45(3):211-7. doi: 10.1111/jop.12345. Epub 2015 Jul 27.

Oral lichen planus: salival biomarkers cortisol, immunoglobulin A, adiponectin.

Author information

1
Oral Medicine, University Dental Clinic, University of Murcia, Murcia, Spain.
2
Department of Animal Medicine and Surgery, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Murcia, Spain.

Abstract

BACKGROUND:

Oral lichen planus (OLP) is a chronic mucocutaneous disease, inflammatory and autoimmune in character, in which the pathogenesis is not fully understood. Psychological stress has also been implicated in triggering or exacerbating the disease.

OBJECTIVE:

The aim of this study was to evaluate the psychological profile, sleep, and salivary biological markers-cortisol, immunoglobin A (IgA), and adiponectin - in patients with oral lichen planus (OLP).

METHODS:

The sample consisted of 65 patients (33 with OLP and 32 control patients). Patients completed hospital anxiety and depression scales (HADD, HADA). Questionnaires were used to assess sleepiness: the Pittsburgh sleep quality index (PSQI) and the Epworth sleepiness scale (ESS). A visual analog scale (VAS) was used for rating pain. Unstimulated whole saliva was evaluated, together with total proteins: cortisol, IgA, and adiponectin.

RESULTS:

Patients with OLP obtained significantly higher HADA and PSQI scores than control subjects (P = 0.001, P = 0.012, respectively). Total salivary protein (flow at rest) analysis found that total proteins were higher in the OLP group (P = 0.001). In the OLP group, IgA was 80.3 ± 51.3 vs. the control group 48.9 ± 32.8 (P = 0.005). Mean cortisol was 0.5 ± 0.3 μg/dl in the OLP group vs. 0.4 ± 0.2 μg/dl in the control group (P = 0.010). The OLP group showed a correlation between the HADA variable and pain (r = 0.358; P = 0.041), HADD (r = 0.568; P = 0.001), and PSQI (r = 0.537; P = 0.001).

CONCLUSIONS:

OLP patients presented worse psychological profiles and sleep disturbances, as well as higher values for IgA, cortisol, and total proteins than control subjects.

KEYWORDS:

IgA; adiponectin; anxiety; cortisol; lichen planus; saliva

PMID:
26216173
DOI:
10.1111/jop.12345
[Indexed for MEDLINE]

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