Format

Send to

Choose Destination
Zhong Yao Cai. 2015 Jan;38(1):89-92.

[Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata].

[Article in Chinese]

Abstract

OBJECTIVE:

To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.

METHODS:

The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice.

RESULTS:

Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), moslosooflavone (9), mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).

CONCLUSION:

All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.

PMID:
26214875
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center