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Nat Neurosci. 2015 Sep;18(9):1230-2. doi: 10.1038/nn.4068. Epub 2015 Jul 27.

Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections.

Author information

1
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
2
Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University, Jerusalem, Israel.
3
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
4
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Abstract

It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

PMID:
26214370
PMCID:
PMC4551610
DOI:
10.1038/nn.4068
[Indexed for MEDLINE]
Free PMC Article

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