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Sens Actuators B Chem. 2015 Dec 31;221:379-385.

Development of a cobinamide-based end-of-service-life indicator for detection of hydrogen cyanide gas.

Author information

1
Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health/National Personal Protective Technology Laboratory (CDC/NIOSH/NPPTL), 1095 Willowdale Road, Morgantown, WV 26505, USA.
2
113 Snee Drive, Jefferson Hills, PA 15025, USA.
3
Department of Chemistry and Biochemistry, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093, USA.
4
Department of Medicine, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093, USA.
5
C. Eugene Bennett Department of Chemistry, 217 Clark Hall, West Virginia University, Morgantown, WV 26506, USA.

Abstract

We describe an inexpensive paper-based sensor for rapid detection of low concentrations (ppm) of hydrogen cyanide gas. A piece of filter paper pre-spotted with a dilute monocyanocobinamide [CN(H2O)Cbi] solution was placed on the end of a bifurcated optical fiber and the reflectance spectrum of the CN(H2O)Cbi was monitored during exposure to 1.0-10.0 ppm hydrogen cyanide gas. Formation of dicyanocobinamide yielded a peak at 583 nm with a simultaneous decrease in reflectance from 450-500 nm. Spectral changes were monitored as a function of time at several relative humidity values: 25, 50, and 85% relative humidity. With either cellulose or glass fiber papers, spectral changes occurred within 10 s of exposure to 5.0 ppm hydrogen cyanide gas (NIOSH recommended short-term exposure limit). We conclude that this sensor could provide a real-time end-of-service-life alert to a respirator user.

KEYWORDS:

Cobinamide; Diffuse reflectance; End-of-service-life indicator; Hydrogen cyanide; Optical sensor; Paper sensor

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