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Food Chem. 2016 Jan 1;190:1174-1181. doi: 10.1016/j.foodchem.2015.06.076. Epub 2015 Jun 23.

Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides.

Author information

1
Department of Food Science and Engineering, School of Chemical Engineering & Technology, Harbin Institute of Technology, No. 73 Huanghe Road, Nangang District, Harbin, Heilongjiang Province 150090, PR China; Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standard & Testing Technology for Agro-Product, Chinese Academy of Agricultural Sciences, No. 12 South Street, Zhongguancun, Haidian District, Beijing 100081, PR China.
2
Department of Food Science and Engineering, School of Chemical Engineering & Technology, Harbin Institute of Technology, No. 73 Huanghe Road, Nangang District, Harbin, Heilongjiang Province 150090, PR China; Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standard & Testing Technology for Agro-Product, Chinese Academy of Agricultural Sciences, No. 12 South Street, Zhongguancun, Haidian District, Beijing 100081, PR China; Key Laboratory of Agrifood Safety and Quality, Ministry of Agriculture, No. 12 Zhongguancun South Street, Haidian District, Beijing 100081, PR China. Electronic address: w_jing2001@126.com.
3
Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standard & Testing Technology for Agro-Product, Chinese Academy of Agricultural Sciences, No. 12 South Street, Zhongguancun, Haidian District, Beijing 100081, PR China; Key Laboratory of Agrifood Safety and Quality, Ministry of Agriculture, No. 12 Zhongguancun South Street, Haidian District, Beijing 100081, PR China.

Abstract

Chitosan and chitosan oligosaccharides (COS) have been reported to possess various biomedical properties, including antimicrobial activities, immuno-enhancing effects, and anti-tumour activities. COS have attracted considerable interest due to their physicochemical properties, and potential applications in the food and pharmaceutical industries, especially in cancer therapies. This paper describes the preparation of COS and their physicochemical properties, and modification, which aids understanding of their biological activities. Based on the latest reports, several biological and anti-tumour activities of COS will be discussed. The proposed anti-tumour mechanisms of COS are summarised, to provide comprehensive insights into research on the molecular level. Finally, the potential applications and future development of the biopolymer will be discussed.

KEYWORDS:

Anti-tumour; Biological activities; Chitosan; Chitosan oligosaccharides; Mechanism; Physicochemical

PMID:
26213092
DOI:
10.1016/j.foodchem.2015.06.076
[Indexed for MEDLINE]

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