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Neuron. 2015 Aug 5;87(3):657-70. doi: 10.1016/j.neuron.2015.06.037. Epub 2015 Jul 23.

Functional System and Areal Organization of a Highly Sampled Individual Human Brain.

Author information

1
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: laumannt@wusm.wustl.edu.
2
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
3
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
4
Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA.
5
Department of Psychology, Washington University in St. Louis, St. Louis, MO 63110, USA.
6
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychology, Washington University in St. Louis, St. Louis, MO 63110, USA.
7
VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA.
8
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
9
Center for Investigating Healthy Minds at the Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
10
Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA; Imaging Research Center, University of Texas at Austin, Austin, TX 78712, USA; Department of Psychology, Stanford University, Stanford, CA 94305, USA.
11
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Resting state functional MRI (fMRI) has enabled description of group-level functional brain organization at multiple spatial scales. However, cross-subject averaging may obscure patterns of brain organization specific to each individual. Here, we characterized the brain organization of a single individual repeatedly measured over more than a year. We report a reproducible and internally valid subject-specific areal-level parcellation that corresponds with subject-specific task activations. Highly convergent correlation network estimates can be derived from this parcellation if sufficient data are collected-considerably more than typically acquired. Notably, within-subject correlation variability across sessions exhibited a heterogeneous distribution across the cortex concentrated in visual and somato-motor regions, distinct from the pattern of intersubject variability. Further, although the individual's systems-level organization is broadly similar to the group, it demonstrates distinct topological features. These results provide a foundation for studies of individual differences in cortical organization and function, especially for special or rare individuals. VIDEO ABSTRACT.

PMID:
26212711
PMCID:
PMC4642864
DOI:
10.1016/j.neuron.2015.06.037
[Indexed for MEDLINE]
Free PMC Article

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