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Addiction. 2015 Dec;110(12):1953-62. doi: 10.1111/add.13076. Epub 2015 Sep 22.

Cocaine-specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse.

Author information

1
Red de Trastornos Adictivos, Universidad de Granada, Granada, Spain.
2
Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain.
3
Cognitive Neuroscience Unit, Deakin University, Melbourne, Australia.
4
Centro Provincial de Drogodependencias, Diputación de Granada, Granada, Spain.
5
Department of Psychology, Universidad de Jaén, Jaén, Spain.
6
School of Psychology, Universidad de Huelva, Huelva, Spain.
7
School of Psychological Sciences, Monash University, Melbourne, Australia.

Abstract

AIMS:

To contrast functional connectivity on ventral and dorsal striatum networks in cocaine dependence relative to pathological gambling, via a resting-state functional connectivity approach; and to determine the association between cocaine dependence-related neuroadaptations indexed by functional connectivity and impulsivity, compulsivity and drug relapse.

DESIGN:

Cross-sectional study of 20 individuals with cocaine dependence (CD), 19 individuals with pathological gambling (PG) and 21 healthy controls (HC), and a prospective cohort study of 20 CD followed-up for 12 weeks to measure drug relapse.

SETTING AND PARTICIPANTS:

CD and PG were recruited through consecutive admissions to a public clinic specialized in substance addiction treatment (Centro Provincial de Drogodependencias) and a public clinic specialized in gambling treatment (AGRAJER), respectively; HC were recruited through community advertisement in the same area in Granada (Spain).

MEASUREMENTS:

Seed-based functional connectivity in the ventral striatum (ventral caudate and ventral putamen) and dorsal striatum (dorsal caudate and dorsal putamen), the Kirby delay-discounting questionnaire, the reversal-learning task and a dichotomous measure of cocaine relapse indicated with self-report and urine tests.

FINDINGS:

CD relative to PG exhibit enhanced connectivity between the ventral caudate seed and subgenual anterior cingulate cortex, the ventral putamen seed and dorsomedial pre-frontal cortex and the dorsal putamen seed and insula (P≤0.001, kE=108). Connectivity between the ventral caudate seed and subgenual anterior cingulate cortex is associated with steeper delay discounting (P≤0.001, kE=108) and cocaine relapse (P≤0.005, kE=34).

CONCLUSIONS:

Cocaine dependence-related neuroadaptations in the ventral striatum of the brain network are associated with increased impulsivity and higher rate of cocaine relapse.

KEYWORDS:

Cocaine; compulsivity; gambling; impulsivity; relapse; striatum

PMID:
26212416
DOI:
10.1111/add.13076
[Indexed for MEDLINE]

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