Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. Production, isolation, characterization and biological properties

J A Matson; J A Bush

doi:10.7164/antibiotics.42.1763

Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. Production, isolation, characterization and biological properties

J Antibiot (Tokyo). 1989 Dec;42(12):1763-7. doi: 10.7164/antibiotics.42.1763.

Authors

J A Matson¹, J A Bush

Affiliation

¹ Pharmaceutical Research and Development Division, Bristol-Myers Company, Wallingford, Connecticut 06492.

PMID: 2621159
DOI: 10.7164/antibiotics.42.1763

Abstract

A new antitumor antibiotic, sandramycin, was isolated from cultured broth of a Nocardioides sp. (ATCC 39419) and purified by solvent partition and column chromatography. Sandramycin, a new depsipeptide, was moderately active in vitro against Gram-positive organisms and in vivo against leukemia P388 in mice.

MeSH terms

Animals
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / therapeutic use
Chemical Phenomena
Chemistry
Gram-Positive Bacteria / drug effects
Leukemia P388 / drug therapy
Mice
Microbial Sensitivity Tests
Nocardiaceae / analysis
Peptides, Cyclic / isolation & purification
Peptides, Cyclic / therapeutic use
Quinolines / isolation & purification*
Quinolines / therapeutic use

Substances

Antibiotics, Antineoplastic
Peptides, Cyclic
Quinolines
sandramycin