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Curr Opin Microbiol. 2015 Dec;28:10-7. doi: 10.1016/j.mib.2015.06.017. Epub 2015 Jul 25.

The parasexual lifestyle of Candida albicans.

Author information

1
Department of Molecular Microbiology and Immunology, Brown University, 171 Meeting St, Providence, RI 02912, United States. Electronic address: Richard_Bennett@brown.edu.

Abstract

Candida albicans is both a prevalent human commensal and the most commonly encountered human fungal pathogen. This lifestyle is dependent on the ability of the fungus to undergo rapid genetic and epigenetic changes, often in response to specific environmental cues. A parasexual cycle in C. albicans has been defined that includes several unique properties when compared to the related model yeast, Saccharomyces cerevisiae. Novel features include strict regulation of mating via a phenotypic switch, enhanced conjugation within a sexual biofilm, and a program of concerted chromosome loss in place of a conventional meiosis. It is expected that several of these adaptations co-evolved with the ability of C. albicans to colonize the mammalian host.

PMID:
26210747
PMCID:
PMC4688137
DOI:
10.1016/j.mib.2015.06.017
[Indexed for MEDLINE]
Free PMC Article

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