Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Causes Control. 2015 Oct;26(10):1365-73. doi: 10.1007/s10552-015-0635-z. Epub 2015 Jul 26.

Impact of pre-diagnosis behavior on risk of death from esophageal cancer: a systematic review and meta-analysis.

Author information

  • 1Centre for Research in Mathematics, University of Western Sydney, Sydney, NSW, Australia. p.fahey@uws.edu.au.
  • 2School of Science and Health, University of Western Sydney, Sydney, NSW, Australia. p.fahey@uws.edu.au.
  • 3Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • 4School of Science and Health, University of Western Sydney, Sydney, NSW, Australia.
  • 5Centre for Research in Mathematics, University of Western Sydney, Sydney, NSW, Australia.
  • 6School of Computing, Engineering and Mathematics, University of Western Sydney, Sydney, NSW, Australia.
  • 7QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Abstract

PURPOSE:

Most people diagnosed with esophageal cancer will die from their disease, but it is not known whether survival is influenced by pre-morbid behavior. We undertook a systematic review and meta-analysis to investigate the impact of pre-diagnosis behavior on risk of death for esophageal cancer.

METHODS:

We performed a systematic review of studies reporting on the relationship between pre-diagnosis smoking, alcohol consumption, overweight and obesity, physical activity and regular consumption of nonsteroidal anti-inflammatory drugs, and risk of death from esophageal squamous cell carcinoma (ESCC) and adenocarcinomas (EACs). Study characteristics are presented and aggregate results are compiled using meta-analysis.

RESULTS:

From an initial pool of 644 non-duplicate records, 13 articles arising from 12 studies met the inclusion criteria. Considerable variation was observed between studies in location, measurement categories, adjustment for other risks, and results. Pooled estimates suggested that for ESCC pre-diagnosis smoking was associated with a 1.19 times [95 % confidence interval (CI) 1.04-1.36] increased risk of death and pre-diagnosis alcohol consumption with a 1.36 times increased risk of death (95 % CI 1.15-1.61). No significant effects were observed for EAC. We observed a lower risk of death for both ESCC and EAC associated with high pre-diagnosis body mass index (BMI) ≥25 kg/m(2) (ESCC hazard ratio 0.80, 95 % CI 0.67-0.95; EAC 0.80, 95 % CI 0.68-0.95), although there was significant heterogeneity across studies.

CONCLUSIONS:

Our findings suggest that a number of modifiable pre-diagnosis risk factors have a carryover effect on the risk of death from esophageal cancer. These include smoking, drinking alcohol, and BMI.

KEYWORDS:

Esophageal adenocarcinoma; Esophageal squamous cell carcinoma; Health behavior; Risk of death

PMID:
26210679
DOI:
10.1007/s10552-015-0635-z
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center