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J Perianesth Nurs. 2015 Aug;30(4):308-20. doi: 10.1016/j.jopan.2014.03.011. Epub 2015 May 15.

Lipid Emulsion in Treatment of Local Anesthetic Toxicity.


Epidural, spinal, regional, local, and intravenous administration of local anesthetics (LAs) is a cornerstone of anesthetic practice. LA toxicity is a grave consequence that is of great significance to anesthesia providers. Outcomes of LA toxicity range from inconvenient symptoms such as tinnitus, twitching, and hypotension to seizures; cardiovascular or respiratory collapse; and death. Lipid emulsion has emerged as a potential "magic bullet" in treating LA toxicity. This literature review provides background information and proposed mechanisms of action for LAs and lipid emulsion as well as animal experiments and a case report that speak to the effectiveness of lipid emulsion in the face of LA toxicity.


lipid emulsion; lipid rescue; local anesthetic; regional anesthesia; toxicity

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