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Trends Biotechnol. 2015 Sep;33(9):496-503. doi: 10.1016/j.tibtech.2015.06.011. Epub 2015 Jul 22.

Proteobacteria: microbial signature of dysbiosis in gut microbiota.

Author information

1
Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul 130-701, Korea.
2
Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul 130-701, Korea. Electronic address: baejw@khu.ac.kr.

Abstract

Recent advances in sequencing techniques, applied to the study of microbial communities, have provided compelling evidence that the mammalian intestinal tract harbors a complex microbial community whose composition is a critical determinant of host health in the context of metabolism and inflammation. Given that an imbalanced gut microbiota often arises from a sustained increase in abundance of the phylum Proteobacteria, the natural human gut flora normally contains only a minor proportion of this phylum. Here, we review studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community. We also propose that an increased prevalence of Proteobacteria is a potential diagnostic signature of dysbiosis and risk of disease.

KEYWORDS:

Proteobacteria; dysbiosis; microbiota

PMID:
26210164
DOI:
10.1016/j.tibtech.2015.06.011
[Indexed for MEDLINE]

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