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Ticks Tick Borne Dis. 2015 Sep;6(6):802-4. doi: 10.1016/j.ttbdis.2015.07.007. Epub 2015 Jul 17.

A case of Francisella tularensis subspecies holarctica in China.

Author information

1
Department of Plague, National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China. Electronic address: wangyanhua@icdc.cn.
2
Xicheng District Center for Disease Prevention and Control, Beijing, China.
3
Peking University First Hospital, Beijing, China.
4
Department of Plague, National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
5
Beijing Genomics Institute - Shenzhen, Shenzhen, China.

Abstract

We report a highly unusual case of ulceroglandular tularemia in Beijing, China. The serological texting, and sequencing of three specific genes by PCR analysis, suggested that this case was infected by Francisella tularensis. Next, using 15 canonical single-nucleotide polymorphisms and insertion-deletion markers (SNPs-INDELs) and five variable-number tandem repeat loci (VNTRs), this case was assigned to a known clade from Russia, and not to the four clades that were previously identified, including previous Chinese isolates. The case that is reported herein provides evidence of type B tularemia in Beijing, and it demonstrates unprecedented levels of diversity of the Chinese variant of F. tularensis.

KEYWORDS:

China; Francisella tularensis subsp. holarctica; INDEL; MLVA; Phylogeography; SNP; Tularemia; canSNP

PMID:
26210091
DOI:
10.1016/j.ttbdis.2015.07.007
[Indexed for MEDLINE]

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