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J Cell Commun Signal. 2015 Sep;9(3):283-4. doi: 10.1007/s12079-015-0301-y. Epub 2015 Jul 25.

Come together, right now….

Author information

1
Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada. hermie@sickkids.ca.

Abstract

Editing the genome using approaches like TALEN and siRNA are already well tested. The new kid on the block is CRISPR-Cas9. CRISPR-Cas9 is rapidly evolving with impressive refinements for specificity, eliminating off-target effects, and versatility. One can adjust constructs and conditions to produce opposite effects on the genome and for a specific purpose. The nuances of the system, the means to significantly reduce off-targeting, and numerous applications are now emerging rapidly. This B&B commentary looks forward into how the CRISPR-Cas9 tool might serve the CCN field.

KEYWORDS:

CCN applications; CRISPR-Cas9; Correcting human disease; Genome editing

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