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J Cell Commun Signal. 2015 Sep;9(3):283-4. doi: 10.1007/s12079-015-0301-y. Epub 2015 Jul 25.

Come together, right now….

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Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.


Editing the genome using approaches like TALEN and siRNA are already well tested. The new kid on the block is CRISPR-Cas9. CRISPR-Cas9 is rapidly evolving with impressive refinements for specificity, eliminating off-target effects, and versatility. One can adjust constructs and conditions to produce opposite effects on the genome and for a specific purpose. The nuances of the system, the means to significantly reduce off-targeting, and numerous applications are now emerging rapidly. This B&B commentary looks forward into how the CRISPR-Cas9 tool might serve the CCN field.


CCN applications; CRISPR-Cas9; Correcting human disease; Genome editing

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