Format

Send to

Choose Destination
Colloids Surf B Biointerfaces. 2015 Oct 1;134:235-9. doi: 10.1016/j.colsurfb.2015.07.008. Epub 2015 Jul 13.

Folate-polydiacetylene-liposome for tumor targeted drug delivery and fluorescent tracing.

Author information

1
Department of Chemistry, Institute of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China.
2
Department of Chemistry, Institute of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China. Electronic address: anxueqin@ecust.edu.cn.

Abstract

A novel folate-polydiacetylene-liposome (FP-PL) with both targeted drug delivery and fluorescence tracing was prepared by thin film rehydration method. The simulated drug delivery was performed in Bcap-37 breast cancer cells and Hs578Bst normal cells in vitro. The internalization and distribution of FP-PLs in the cells were presented by fluorescence cell imaging. The results show that the FP-PLs possess low cytotoxicity, good biocompatibility and better targeting efficiency in comparison to polydiacetylene-liposomes (P-PLs).

KEYWORDS:

Fluorescent imaging; Folic acid; Liposome; Polydiacetylene; Targeted drug delivery

PMID:
26208294
DOI:
10.1016/j.colsurfb.2015.07.008
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center