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Int J Hyg Environ Health. 2015 Oct;218(7):639-44. doi: 10.1016/j.ijheh.2015.07.002. Epub 2015 Jul 9.

Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study.

Author information

1
Epidemiology Branch, National Institute of Environmental Health Sciences/National Institute of Health, Research Triangle Park, NC 27709, USA; Carter Consulting, Inc., Atlanta, GA 30345, USA.
2
Epidemiology Branch, National Institute of Environmental Health Sciences/National Institute of Health, Research Triangle Park, NC 27709, USA.
3
Department of Special Education, National Taiwan Normal University, Taipei, Taiwan.
4
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan.
5
Department of Pediatrics, Chung Shan Medical University Hospital, Taichung City, Taiwan.
6
Epidemiology Branch, National Institute of Environmental Health Sciences/National Institute of Health, Research Triangle Park, NC 27709, USA; Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan; Department of Public Health, National Defense Medical Center, Taipei, Taiwan. Electronic address: slwang@nhri.org.tw.

Abstract

BACKGROUND:

Perfluoroalkyl substances (PFASs) are a group of fluorinated organic substances that are widely used in consumer products and are often detectable in human tissues. Human studies on prenatal exposure to PFASs and neurodevelopment in children are few and inconsistent.

METHODS:

In the Taiwan Maternal and Infant Cohort Study, we collected serum samples from pregnant women during the third trimester and measured concentrations of 9 PFASs using a high performance liquid chromatography system. A subsample of their children was assessed with full scale intelligence quotient (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ) at both age 5 (n=120) and 8 years (n=120). We used multivariate linear regression models to examine prenatal PFAS exposure in relation to IQ scores at each age period.

RESULTS:

Prenatal perfluoroundecanoic acid (PFUnDA) concentrations were inversely associated with children's PIQ scores at age 5 years, with an adjusted coefficient (β) of -1.6 (95% confidence interval [CI]: (-3.0, -0.2). When children reached 8 years, most of the prenatal PFASs showed inverse association with children's FSIQ, VIQ and PIQ scores. Among them, prenatal perfluorononanoic acid (PFNA) reached significance. Children with higher prenatal PFNA levels had lower VIQ with an adjusted β of -2.1 (95% CI: -3.9, -0.2).

CONCLUSIONS:

We found two prenatal PFAS exposure, both long-chain PFASs, in association with decreased IQ test scores in children. Our findings suggest more studies on long-chain PFASs and children's neurodevelopment.

KEYWORDS:

Children; IQ; Perfluoroalkyl substances; Prenatal exposure

PMID:
26205657
PMCID:
PMC5435232
DOI:
10.1016/j.ijheh.2015.07.002
[Indexed for MEDLINE]
Free PMC Article

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