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Nat Rev Cancer. 2015 Aug;15(8):484-98. doi: 10.1038/nrc3967.

Adiposity and cancer risk: new mechanistic insights from epidemiology.

Author information

1
Institute of Cancer Sciences, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
2
Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, Bern CH-3012, Switzerland.

Abstract

Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for many common adult cancers. Over the past decade, epidemiological data have shown that adiposity-cancer risk associations are specific for gender, site, geographical population, histological subtype and molecular phenotype. The biological mechanisms underpinning these associations are incompletely understood but need to take account of the specificities observed in epidemiology to better inform future prevention strategies.

PMID:
26205341
DOI:
10.1038/nrc3967
[Indexed for MEDLINE]

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