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Oral Dis. 2015 Oct;21(7):886-93. doi: 10.1111/odi.12360. Epub 2015 Sep 1.

Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans.

Author information

1
Departments of Dental Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
2
Department of Epidemiology for Community health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
3
Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
4
Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
5
Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
6
Kyoto Industrial Health Association, Kyoto, Japan.
7
Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, Osaka, Japan.
8
Department of Neurology, University of Louisville, KY, USA.

Abstract

OBJECTIVE:

Cerebral hemorrhage has been shown to occur in animals experimentally infected with Streptococcus mutans carrying the collagen-binding Cnm gene. However, the relationship between cerebral microbleeds and oral hygiene, with a focus on Cnm gene-positive S. mutans infection, remains unclear.

MATERIAL AND METHODS:

One hundred and thirty-nine subjects participated. The presence or absence of Cnm-positive S. mutans and its collagen-binding activity were investigated using saliva samples, and relationship with cerebral microbleeds detected on MRI investigated, including clinical information and oral parameters.

RESULTS:

Fifty-one subjects were identified as Cnm-positive S. mutans carriers (36.7%), with cerebral microbleeds being detected in 43 (30.9%). A significantly larger number of subjects carried Cnm-positive S. mutans in the cerebral microbleeds (+) group. S. mutans with Cnm collagen-binding ability was detected in 39 (28.1%) of all subjects, and the adjusted odds ratio for cerebral microbleeds in the Cnm-positive group was 14.4. Regarding the presence of cerebral microbleeds, no significant differences were noted in the number of remaining teeth, dental caries, or in classic arteriosclerosis risk factors.

CONCLUSIONS:

The occurrence of cerebral microbleeds was higher in subjects carrying Cnm-positive S. mutans, indicating that the presence of Cnm-positive S. mutans increases cerebral microbleeds, and is an independent risk for the development of cerebrovascular disorders.

KEYWORDS:

Cnm-positive Streptococcus Mutans; Magnetic Resonance Imaging; collagen-binding protein; intracranial hemorrhage; microbleeds; stroke

PMID:
26205098
DOI:
10.1111/odi.12360
[Indexed for MEDLINE]

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