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Molecules. 2015 Jul 20;20(7):13041-54. doi: 10.3390/molecules200713041.

Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver.

Author information

1
Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Yangchon-ku, Seoul 158-710, Korea. melonlemon05@naver.com.
2
Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Yangchon-ku, Seoul 158-710, Korea. mmac82@naver.com.
3
Life Science Research Institute, Novarex Co., Ltd, Ochang, Cheongwon, Chungbuk 363-885, Korea. kkm3507@novarex.co.kr.
4
College of Pharmacy, Pusan National University, Pusan 609-735, Korea. youngjung@pusan.ac.kr.
5
Life Science Research Institute, Novarex Co., Ltd, Ochang, Cheongwon, Chungbuk 363-885, Korea. jcjung10@yahoo.co.kr.
6
Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Yangchon-ku, Seoul 158-710, Korea. skoh@ewha.ac.kr.

Abstract

This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases.

KEYWORDS:

anti-inflammation; glycyrrhizic acid; hepatoprotective effect; licorice extract; liquiritin; oxidative liver damage

PMID:
26205049
PMCID:
PMC6332102
DOI:
10.3390/molecules200713041
[Indexed for MEDLINE]
Free PMC Article

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