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Org Biomol Chem. 2015 Sep 7;13(33):8906-11. doi: 10.1039/c5ob01125f.

An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin.

Author information

1
Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China. jzhou@chem.ecnu.edu.cn.

Abstract

We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.

PMID:
26205007
DOI:
10.1039/c5ob01125f
[Indexed for MEDLINE]

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