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Curr Opin Immunol. 2015 Oct;36:67-72. doi: 10.1016/j.coi.2015.07.003. Epub 2015 Jul 21.

Type 2 responses at the interface between immunity and fat metabolism.

Author information

1
Cardiovascular Research Institute, University of California San Francisco, San Francisco, 94158-9001, USA.
2
Cardiovascular Research Institute, University of California San Francisco, San Francisco, 94158-9001, USA; Departments of Physiology and Medicine, University of California San Francisco, San Francisco, 94158-9001, USA. Electronic address: ajay.chawla@ucsf.edu.

Abstract

Adipose tissue resident leukocytes are often cast solely as the effectors of obesity and its attendant pathologies; however, recent observations have demonstrated that these cells support and effect 'healthy' physiologic function as well as pathologic dysfunction. Importantly, these two disparate outcomes are underpinned by similarly disparate immune programs; type 2 responses instruct and promote metabolic normalcy, while type 1 responses drive tissue dysfunction. In this Review, we summarize the literature regarding type 2 immunity's role in adipose tissue physiology and allude to its potential therapeutic implications.

PMID:
26204571
PMCID:
PMC4593747
DOI:
10.1016/j.coi.2015.07.003
[Indexed for MEDLINE]
Free PMC Article

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