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Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 5;152:119-25. doi: 10.1016/j.saa.2015.07.063. Epub 2015 Jul 13.

A rapid and sensitive assay for determination of doxycycline using thioglycolic acid-capped cadmium telluride quantum dots.

Author information

1
Professor Massoumi Laboratory, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran. Electronic address: tashkhourian@susc.ac.ir.
2
Professor Massoumi Laboratory, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran.

Abstract

A rapid, simple and inexpensive spectrofluorimetric sensor for determination of doxycycline based on its interaction with thioglycolic acid-capped cadmium telluride quantum dots (TGA/CdTe QDs) has been developed. Under the optimum experimental conditions, the sensor exhibited a fast response time of <10s. The results revealed that doxycycline could quench the fluorescence of TGA/CdTe QDs via electron transfer from the QDs to doxycycline through a dynamic quenching mechanism. The sensor permitted determination of doxycycline in a concentration range of 1.9×10(-6)-6.1×10(-5)molL(-1) with a detection limit of 1.1×10(-7)molL(-1). The sensor was applied for determination of doxycycline in honey and human serum samples.

KEYWORDS:

Cadmium telluride quantum dots; Doxycycline; Fluorescence detection; Sonochemical synthesis

PMID:
26204505
DOI:
10.1016/j.saa.2015.07.063
[Indexed for MEDLINE]

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