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PLoS One. 2015 Jul 23;10(7):e0133766. doi: 10.1371/journal.pone.0133766. eCollection 2015.

Spontaneous Activity Associated with Delusions of Schizophrenia in the Left Medial Superior Frontal Gyrus: A Resting-State fMRI Study.

Author information

1
Department of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
2
Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, PR China; Mental Health Center, School of Medicine, Zhe Jiang University, Hangzhou, Zhejiang, PR China.
3
Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, PR China.
4
Hangzhou First People's Hospital, Hangzhou, Zhejiang, PR China.
5
Department of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
6
Alpert Medical School of Brown University, Richmond St., Providence, RI, United States of America.
7
Department of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China; Mental Health Education and Counseling Center, Zhejiang University, Hangzhou, Zhejiang, PR China.
8
Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, PR China.

Abstract

Delusions of schizophrenia have been found to be associated with alterations of some brain regions in structure and task-induced activation. However, the relationship between spontaneously occurring symptoms and spontaneous brain activity remains unclear. In the current study, 14 schizophrenic patients with delusions and 14 healthy controls underwent a resting-state functional magnetic resonance imaging (RS-fMRI) scan. Patients with delusions of schizophrenia patients were rated with Positive and Negative Syndrome Scale (PANSS) and Characteristics of Delusional Rating Scale (CDRS). Regional homogeneity (ReHo) was calculated to measure the local synchronization of the spontaneous activity in a voxel-wise way. A two-sample t-test showed that ReHo of the right anterior cingulate gyrus and left medial superior frontal gyrus were higher in patients, and ReHo of the left superior occipital gyrus was lower, compared to healthy controls. Further, among patients, correlation analysis showed a significant difference between delusion scores of CRDS and ReHo of brain regions. ReHo of the left medial superior frontal gyrus was negatively correlated with patients' CDRS scores but not with delusional PANSS scores. These results suggested that altered local synchronization of spontaneous brain activity may be related to the pathophysiology of delusion in schizophrenia.

PMID:
26204264
PMCID:
PMC4512714
DOI:
10.1371/journal.pone.0133766
[Indexed for MEDLINE]
Free PMC Article

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