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Arch Dis Child. 2016 Feb;101(2):185-9. doi: 10.1136/archdischild-2014-307961. Epub 2015 Jul 22.

What diseases are causally linked to vitamin D deficiency?

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University of Auckland, Auckland, New Zealand Department of Endocrinology, Auckland District Health Board, Auckland, New Zealand.


The classical clinical consequence of vitamin D deficiency is osteomalacia, presenting as rickets in children. This remains a common problem in parts of the Middle East and the Indian subcontinent, and occurs when serum 25-hydroxyvitamin D levels are <25 nmol/L. Osteomalacia remains the only problem that is unequivocally a consequence of vitamin D deficiency. Low levels of 25-hydroxyvitamin D are observed in a wide range of conditions, but consistent trial evidence of amelioration of these conditions with vitamin D is lacking. Monotherapy with vitamin D has not been found to be effective in meta-analyses of trials assessing its effects on bone density, fractures or falls. At present, supplements should be advised for individuals at risk of having serum 25-hydroxyvitamin D levels in the 25-40 nmol/L range, or below, with a view to prevention of osteomalacia.


Bone Disease; Bone Metabolism

[Indexed for MEDLINE]

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