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Cell Differ Dev. 1989 Dec;28(3):211-7.

Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer.

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Department of Zoophysiology, Universit├Ąt GHS Essen, F.R.G.


When Xenopus blastula or early gastrula ectoderm is disaggregated and cells are kept dispersed for up to 5 h prior to reaggregation, the resulting spheres will differentiate into large neural structures. In contrast, dissociated and immediately reaggregated ectoderm will only differentiate into ciliated epidermis (so-called 'atypical epidermis'). Ectoderm treated with mesoderm-inducing XTC-conditioned medium during the period of reaggregation immediately after disaggregation will only form one- or two-cell types (notochord and somites) only. Ectoderm treated with XTC-factor prior to disaggregation will differentiate into a large variety of cell types.

[Indexed for MEDLINE]

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