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J Oral Rehabil. 2015 Dec;42(12):956-66. doi: 10.1111/joor.12324. Epub 2015 Jul 22.

Perspectives on next steps in classification of oro-facial pain - Part 3: biomarkers of chronic oro-facial pain - from research to clinic.

Author information

1
Department of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
2
Rutgers School of Dental Medicine, Newark, NJ, USA.
3
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
4
Section of Orthodontics, School of Dentistry, University of Naples Federico II, Naples, Italy.
5
Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY, USA.

Abstract

The purpose of this study was to review the current status of biomarkers used in oro-facial pain conditions. Specifically, we critically appraise their relative strengths and weaknesses for assessing mechanisms associated with the oro-facial pain conditions and interpret that information in the light of their current value for use in diagnosis. In the third section, we explore biomarkers through the perspective of ontological realism. We discuss ontological problems of biomarkers as currently widely conceptualised and implemented. This leads to recommendations for research practice aimed to a better understanding of the potential contribution that biomarkers might make to oro-facial pain diagnosis and thereby fulfil our goal for an expanded multidimensional framework for oro-facial pain conditions that would include a third axis.

KEYWORDS:

biomarkers; chronic oro-facial pain; classification; ontology; pain; temporomandibular disorders

PMID:
26200973
PMCID:
PMC4715524
DOI:
10.1111/joor.12324
[Indexed for MEDLINE]
Free PMC Article

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