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J Am Geriatr Soc. 2015 Aug;63(8):1634-9. doi: 10.1111/jgs.13530. Epub 2015 Jul 22.

Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment.

Author information

1
Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Centre Hospitalier Universitaire Toulouse, Toulouse, France.
2
UMR INSERM 1027, University of Toulouse III, Toulouse, France.
3
UMR 825, University of Toulouse III, Toulouse, France.
4
Department of Nuclear Medicine, University Hospital of Toulouse (CHU-Toulouse), Toulouse, France.

Abstract

OBJECTIVES:

To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship.

DESIGN:

Cross-sectional study.

SETTING:

French community-dwelling people.

PARTICIPANTS:

Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self-reported PA and amyloid-β brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n = 268).

MEASUREMENTS:

A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR-).

RESULTS:

Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR- participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E ε4 carriers or noncarriers. PA was not associated with cognitive function.

CONCLUSION:

Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid-β brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimer's disease.

KEYWORDS:

Alzheimer's disease; amyloid plaques; elderly; older adults; physical activity

PMID:
26200930
DOI:
10.1111/jgs.13530
[Indexed for MEDLINE]

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