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Biophys J. 2015 Jul 21;109(2):450-6. doi: 10.1016/j.bpj.2015.06.019.

Threshold of microvascular occlusion: injury size defines the thrombosis scenario.

Author information

1
Center for Theoretical Problems of Physicochemical Pharmacology RAS, Moscow, Russia; Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia. Electronic address: aleksey_belyaev@yahoo.com.
2
Center for Theoretical Problems of Physicochemical Pharmacology RAS, Moscow, Russia; Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; Department of Physics, M. V. Lomonosov Moscow State University, Moscow, Russia; HemaCore LLC, Moscow, Russia.

Abstract

Damage to the blood vessel triggers formation of a hemostatic plug, which is meant to prevent bleeding, yet the same phenomenon may result in a total blockade of a blood vessel by a thrombus, causing severe medical conditions. Here, we show that the physical interplay between platelet adhesion and hemodynamics in a microchannel manifests in a critical threshold behavior of a growing thrombus. Depending on the size of injury, two distinct dynamic pathways of thrombosis were found: the formation of a nonocclusive plug, if injury length does not exceed the critical value, and the total occlusion of the vessel by the thrombus otherwise. We develop a mathematical model that demonstrates that switching between these regimes occurs as a result of a saddle-node bifurcation. Our study reveals the mechanism of self-regulation of thrombosis in blood microvessels and explains experimentally observed distinctions between thrombi of different physical etiology. This also can be useful for the design of platelet-aggregation-inspired engineering solutions.

PMID:
26200881
PMCID:
PMC4621855
DOI:
10.1016/j.bpj.2015.06.019
[Indexed for MEDLINE]
Free PMC Article

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