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Beilstein J Nanotechnol. 2015 Jun 30;6:1432-8. doi: 10.3762/bjnano.6.148. eCollection 2015.

DNA-melamine hybrid molecules: from self-assembly to nanostructures.

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Department of Chemistry, Indian Institute of Technology Patna, Patna 800013, India.
Department of Materials Science and Engineering, Indian Institute of Technology Patna, Patna 800013, India.
Rubber Technology Centre, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.


Single-stranded DNA-melamine hybrid molecular building blocks were synthesized using a phosphoramidation cross-coupling reaction with a zero linker approach. The self-assembly of the DNA-organic hybrid molecules was achieved by DNA hybridization. Following self-assembly, two distinct types of nanostructures in the form of linear chains and network arrays were observed. The morphology of the self-assembled nanostructures was found to depend on the number of DNA strands that were attached to a single melamine molecule.


DNA–organic hybrid; melamine; nanostructures; phosphoramidation; self-assembly

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