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Development. 2015 Jul 15;142(14):2392-6. doi: 10.1242/dev.123737.

The retromer complex in development and disease.

Author information

1
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
2
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA hbellen@bcm.edu.

Abstract

The retromer complex is a multimeric protein complex involved in recycling proteins from endosomes to the trans-Golgi network or plasma membrane. It thus regulates the abundance and subcellular distribution of its cargo within cells. Studies using model organisms show that the retromer complex is involved in specific developmental processes. Moreover, a number of recent studies implicate aberrant retromer function in photoreceptor degeneration, Alzheimer's disease and Parkinson's disease. Here, and in the accompanying poster, we provide an overview of the molecular and cellular mechanisms of retromer-mediated protein trafficking, highlighting key examples of retromer function in vivo.

KEYWORDS:

Alzheimer's disease; Endocytic recycling; Epithelial apical polarity; Heme formation; Parkinson's disease; Photoreceptor degeneration; Retromer; Wingless/Wnt signaling

PMID:
26199408
PMCID:
PMC4510866
DOI:
10.1242/dev.123737
[Indexed for MEDLINE]
Free PMC Article

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