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Lab Med. 2015 Summer;46(3):226-9. doi: 10.1309/LMZYTSO5RHIHV93T.

Rheumatoid Factor, Anti-Cyclic Citrullinated Peptide Antibody, C-Reactive Protein, and Erythrocyte Sedimentation Rate for the Clinical Diagnosis of Rheumatoid Arthritis.

Author information

1
Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China.
2
Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, China.
3
Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China jsq814@hotmail.com.

Abstract

OBJECTIVE:

To explore the value of rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody, C-reactive protein (CRP), and the erythrocyte sedimentation rate (ESR) in the diagnosis of rheumatoid arthritis (RA).

METHODS:

Using rate nephelometry, chemiluminescence microparticle immunoassay (CMIA), and Westergren sedimentation rate testing, we detected RF, anti-CCP antibody, CRP, and ESR in 134 patients with RA and 50 healthy control individuals.

RESULTS:

We observed significant differences in RF, anti-CCP antibody, CRP, and ESR concentrations between the RA and control groups (P <.01). The sensitivity, specificity and accuracy in the diagnosis of RA were 91.0%, 74.4%, and 87.0%, respectively, for RF; 88.0%, 90.4%, and 88.1%, respectively, for anti-CCP antibody; and 90.2%, 83.3%, and 89.5%, respectively, for the detection of RA via the combination of RF and anti-CCP antibody.

CONCLUSION:

Anti-CCP is more specific than the other parameters we reviewed for the diagnosis of RA. Combined detection of the 4 parameters is beneficial when confirming a diagnosis of RA.

KEYWORDS:

C-reactive protein; anti-cyclic citrullinated peptide antibody; clinical diagnosis; erythrocyte sedimentation rate; rheumatoid arthritis; rheumatoid factor

PMID:
26199263
DOI:
10.1309/LMZYTSO5RHIHV93T
[Indexed for MEDLINE]

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