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J Neuroimmunol. 2015 Aug 15;285:57-61. doi: 10.1016/j.jneuroim.2015.05.021. Epub 2015 May 21.

Gender influence in EBV antibody response in multiple sclerosis patients from Kuwait.

Author information

1
Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait. Electronic address: rabeah@hsc.edu.kw.
2
Division of Neurology, Department of Medicine, Amiri Hospital, Kuwait, Kuwait; Neurology Clinic, Department of Medicine, Dasman Diabetes Institute, Kuwait.
3
Molecular Pathology Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait.

Abstract

BACKGROUND:

Epstein-Barr virus (EBV) infection is implicated with multiple sclerosis (MS) risk, exacerbation, and progression. The HLA-DRB1*1501 haplotype is a strong MS risk factor consistently documented in MS populations. There are no studies of EBV infections and HLA-DRB1*1501 haplotype associating with MS from Kuwait where MS prevalence has increased significantly.

OBJECTIVES:

To determine the association of EBV infection with MS incidence, and to investigate HLA-DRB1*1501 as a potential genetic risk factor for MS in Kuwait.

METHODS:

This is a case-control study involving 141 MS patients and 40 healthy controls. Antibody titers against EBV antigens' viral capsid antigen (VCA) and Epstein-Barr nuclear antigen 1 (EBNA1) were measured using enzyme-linked immunosorbent assays. HLA-DRB1*1501 haplotype assessment was done using rs3135005 TaqMan genotyping assay.

RESULTS:

Antibody titers against EBV were significantly elevated in MS patients compared to healthy controls (anti-EBNA1, p=0.008; anti-VCA, p=0.028). MS males had higher antibody titers to EBNA1 than healthy male controls (p=0.005) and female MS patients (p=0.03). HLA-DRB1*1501 haplotype genotypes failed to generate a risk association with MS or EBV antibody titers (p=0.6).

CONCLUSION:

An increased immune response to EBV infection is associated with MS incidence influenced by the type of antigen and sex. HLA-DRB1*1501 haplotype is not associated with MS risk in our Kuwaiti MS cohort.

KEYWORDS:

EBNA1; Epstein–Barr virus; HLA-DRB1*1501; Kuwait; Multiple sclerosis; VCA

PMID:
26198919
DOI:
10.1016/j.jneuroim.2015.05.021
[Indexed for MEDLINE]

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