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Mol Neurobiol. 2016 Aug;53(6):4094-4125. doi: 10.1007/s12035-015-9337-5. Epub 2015 Jul 22.

Oxidative Stress in Neurodegenerative Diseases.

Author information

1
Department of Toxicology, Chair of Toxicology, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30-688, Kraków, Poland.
2
Department of Neurology, Faculty of Medicine, Jagiellonian University, Medical College, Botaniczna 3, 31-503, Krakow, Poland.
3
Department of Toxicology, Chair of Toxicology, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30-688, Kraków, Poland. mal.fil@if-pan.krakow.pl.
4
Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland. mal.fil@if-pan.krakow.pl.

Abstract

The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction.

KEYWORDS:

Alzheimer’s disease; Amyotrophic lateral sclerosis; Antioxidant defense molecule; ESR—electron spin resonance; IST—immuno-spin trapping technique; Non-enzymatic and enzymatic antioxidant; Oxidative stress biomarker; Parkinson’s disease

PMID:
26198567
PMCID:
PMC4937091
DOI:
10.1007/s12035-015-9337-5
[Indexed for MEDLINE]
Free PMC Article

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