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J Int AIDS Soc. 2015 Jul 20;18(4 Suppl 3):19980. doi: 10.7448/IAS.18.4.19980. eCollection 2015.

Antiretroviral pre-exposure prophylaxis implementation in the United States: a work in progress.

Author information

1
The Fenway Institute, Fenway Health, Boston, MA, USA.
2
Beth Israel Deaconess Medical Center, Boston, MA, USA.
3
Harvard Medical School, Boston, MA, USA; khmayer@gmail.com.
4
Stroger Hospital of Cook County/CORE Center, Chicago, IL, USA.
5
San Francisco Department of Health, San Francisco, CA, USA.
6
AIDS Foundation of Chicago, Chicago, IL, USA.
7
AIDS Vaccine Advocacy Coalition, New York, NY, USA.
8
Harvard Medical School, Boston, MA, USA.
9
Gladstone Institute, University of California, San Francisco, CA, USA.

Abstract

INTRODUCTION:

After the initial approval of the use of tenofovir disoproxil fumarate-emtricitabine (TDF/FTC) by the US Food and Drug Administration in 2012 for anti-HIV pre-exposure prophylaxis (PrEP), uptake was initially limited, but more recent community surveys and expert opinion suggest wider acceptance in some key populations.

DISCUSSION:

Demonstration projects are underway to determine the best practices in the United States to identify at-risk individuals in primary care and sexually transmitted disease clinics who could benefit from PrEP. Studies of PrEP in combination with behavioural interventions are being evaluated. Studies to evaluate the use of PrEP by HIV-uninfected women in HIV-discordant couples interested in safe conception are also getting underway. The optimal deployment of PrEP as part of a comprehensive national HIV/AIDS strategy in the United States has been limited by lack of knowledge among some at-risk people and by some medical providers indicating that they do not feel sufficiently knowledgeable and comfortable in prescribing PrEP. Studies are underway to determine how to assist busy clinicians to determine which of their patients could benefit from PrEP. Although most federal health insurance programmes will cover most of the costs associated with PrEP, underinsured patients in states that have not enacted health reform face additional challenges in paying for PrEP medication and appropriate clinical monitoring.

CONCLUSIONS:

PrEP implementation in the United States is a work in progress, with increasing awareness and uptake among some individuals in key populations.

KEYWORDS:

PrEP; pre-exposure prophylaxis; tenofovir-emtricitabine

PMID:
26198345
PMCID:
PMC4509893
DOI:
10.7448/IAS.18.4.19980
[Indexed for MEDLINE]
Free PMC Article

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