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Adv Mater. 2015 Sep 9;27(34):5034-42. doi: 10.1002/adma.201501502. Epub 2015 Jul 21.

A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy.

Author information

1
College of Marine Life Science, Ocean University of China, No. 5 Yushan Road, Qingdao, P. R. China.
2
Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, P. R. China.

Abstract

Novel core-shell tumor-penetrating vesicles consisting of a nanovesicle core with tumor-penetrating ligands and enzymatically degradable polymeric peptides anchored covalently to the core to form a thin polymeric shell are evaluated as drug-delivery systems. This delivery platform demonstrates an enhanced therapeutic efficacy attributed to the synergistic contributions from matrix metalloproteinase (MMP)-responsive drug release as well as improved tumor accumulation and penetration in the tumor microenvironment.

KEYWORDS:

drug delivery; peptides; polymers; self-assembly

PMID:
26198072
DOI:
10.1002/adma.201501502
[Indexed for MEDLINE]

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