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Cytokine. 2015 Dec;76(2):537-544. doi: 10.1016/j.cyto.2015.07.014. Epub 2015 Jul 18.

The role of BAFF in the progression of rheumatoid arthritis.

Author information

1
Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine of Education Ministry of China, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; Department of Pharmacy, Bengbu Medical College, Bengbu 233000, China. Electronic address: weifangmailbox@126.com.
2
Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine of Education Ministry of China, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China.
3
Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine of Education Ministry of China, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China. Electronic address: wwei@ahmu.edu.cn.

Abstract

Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) have been detected in the serum and synovial fluid of RA patients. Moreover, the levels of BAFF increase in cases of autoimmune disease and are correlated with the level of disease activity. As an innate cytokine mediator, BAFF affects the immune response of the synovial microenvironment. In this review, we consider recent observations of BAFF and its receptors in RA progression, as well as the effects of BAFF on the cell-cell interactions network. We also summarize the clinical development of BAFF antagonists for the treatment of RA.

KEYWORDS:

B cell activating factor; BAFF-R; BCMA; Immune cells; Rheumatoid arthritis; TACI

PMID:
26198030
DOI:
10.1016/j.cyto.2015.07.014
[Indexed for MEDLINE]

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