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Nat Prod Commun. 2015 Jun;10(6):995-6.

Synthesis of Resveratrol Glycosides by Plant Glucosyltransferase and Cyclodextrin Glucanotransferase and Their Neuroprotective Activity.


Resveratrol was converted by glucosyltransferase from Phytolacca americana into its 3- and 4'-O-β-D-glucosides. On the other hand, further glycosylation of resveratrol 4'-O-β-D-glucoside by cyclodextrin glucanotransferase gave the 4'-O-β-maltoside, 4'-O-β-maltotrioside, 4'-O-β-maltotetraoside, and 4'-O-β- maltopentaoside of resveratrol. The six resveratrol glycosides synthesized here showed higher phosphodiesterase inhibitory activity than resveratrol.

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