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BMJ Open. 2015 Jul 20;5(7):e008811. doi: 10.1136/bmjopen-2015-008811.

Determining Surgical Complications in the Overweight (DISCOVER): a multicentre observational cohort study to evaluate the role of obesity as a risk factor for postoperative complications in general surgery.

Author information

1
University of Birmingham, School of Cancer Sciences, Birmingham, UK.
2
St James University Hospital, Leeds, UK.
3
University Hospital of Wales, Cardiff, UK.
4
Aintree University Hospital, Liverpool, UK.
5
Imperial College London Medical School, London, UK.
6
University of Sheffield Medical School, Sheffield, UK.
7
University of Glasgow Medical School, Glasgow, UK.
8
University of Bristol Medical School, Bristol, UK.
9
Department of Surgery, University of Edinburgh, Edinburgh, UK.
10
University College London, London, UK.

Abstract

INTRODUCTION:

Obesity is increasingly prevalent among patients undergoing surgery. Conflicting evidence exists regarding the impact of obesity on postoperative complications. This multicentre study aims to determine whether obesity is associated with increased postoperative complications following general surgery.

METHODS AND ANALYSIS:

This prospective, multicentre cohort study will be performed utilising a collaborative methodology. Consecutive adults undergoing open or laparoscopic, elective or emergency, gastrointestinal, bariatric or hepatobiliary surgery will be included. Day case patients will be excluded. The primary end point will be the overall 30-day major complication rate (Clavien-Dindo grade III-V complications). Data will be collected to risk-adjust outcomes for potential confounding factors, such as preoperative cardiac risk. This study will be disseminated through structured medical student networks using established collaborative methodology. The study will be powered to detect a two-percentage point increase in the major postoperative complication rate in obese versus non-obese patients.

ETHICS AND DISSEMINATION:

Following appropriate assessment, an exemption from full ethics committee review has been received, and the study will be registered as a clinical audit or service evaluation at each participating hospital. Dissemination will take place through national and local research collaborative networks.

KEYWORDS:

SURGERY

PMID:
26195471
PMCID:
PMC4513439
DOI:
10.1136/bmjopen-2015-008811
[Indexed for MEDLINE]
Free PMC Article

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