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Clin Geriatr Med. 2015 Aug;31(3):367-74. doi: 10.1016/j.cger.2015.04.005. Epub 2015 May 6.

Sarcopenia as the Biological Substrate of Physical Frailty.

Author information

1
Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome 00168, Italy. Electronic address: francesco.landi@rm.unicatt.it.
2
Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome 00168, Italy.
3
Gérontopôle, University Hospital of Toulouse, 37 Allées Jules Guesde, Toulouse 31000, France.

Abstract

Physical function decreases with aging, which may result in adverse outcomes (eg, disability, loss of independence, institutionalization, death). Physical function impairment is a common trait of frailty and sarcopenia. These two conditions, albeit highly common, have not yet received a unique operational definition, which has impeded their implementation in standard practice. Here, we introduce a conceptual model in which sarcopenia is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. This conceptualization may open new venues for the design of interventions against physical frailty and promote the translation of findings to the clinical arena.

KEYWORDS:

Aging; Disability; Operationalization; Physical performance; Skeletal muscle

PMID:
26195096
DOI:
10.1016/j.cger.2015.04.005
[Indexed for MEDLINE]

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