Format

Send to

Choose Destination
Alzheimers Dement. 2015 Jul;11(7):757-71. doi: 10.1016/j.jalz.2015.05.001.

The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015.

Author information

1
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA. Electronic address: jagust@berkeley.edu.
2
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
3
Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
4
Banner Alzheimer Institute, Phoenix, AZ, USA.
5
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
6
Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.

Abstract

INTRODUCTION:

This article reviews the work done in the Alzheimer's Disease Neuroimaging Initiative positron emission tomography (ADNI PET) core over the past 5 years, largely concerning techniques, methods, and results related to amyloid imaging in ADNI.

METHODS:

The PET Core has used [(18)F]florbetapir routinely on ADNI participants, with over 1600 scans available for download. Four different laboratories are involved in data analysis, and have examined factors such as longitudinal florbetapir analysis, use of [(18)F]fluorodeoxyglucose (FDG)-PET in clinical trials, and relationships between different biomarkers and cognition.

RESULTS:

Converging evidence from the PET Core has indicated that cross-sectional and longitudinal florbetapir analyses require different reference regions. Studies have also examined the relationship between florbetapir data obtained immediately after injection, which reflects perfusion, and FDG-PET results. Finally, standardization has included the translation of florbetapir PET data to a centiloid scale.

CONCLUSION:

The PET Core has demonstrated a variety of methods for the standardization of biomarkers such as florbetapir PET in a multicenter setting.

KEYWORDS:

Alzheimer's disease; Amyloid; Fluorodeoxyglucose; Mild cognitive impairment; PET imaging

PMID:
26194311
PMCID:
PMC4510459
DOI:
10.1016/j.jalz.2015.05.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center