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Alzheimers Dement. 2015 Jul;11(7):734-9. doi: 10.1016/j.jalz.2015.05.005.

Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans.

Author information

1
Department of Neurosciences, University of California San Diego, San Diego, CA, USA. Electronic address: paisen@ucsd.edu.
2
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
3
Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA, USA.
4
Departments of Radiology and Biomedical Imaging, Medicine, Psychiatry and Neurology, University of California San Francisco, San Fransisco, CA, USA.

Abstract

INTRODUCTION:

This article reviews the current status of the Clinical Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI), and summarizes planning for the next stage of the project.

METHODS:

Clinical Core activities and plans were synthesized based on discussions among the Core leaders and external advisors.

RESULTS:

The longitudinal data in ADNI-2 provide natural history data on a clinical trials population and continue to inform refinement and standardization of assessments, models of trajectories, and clinical trial methods that have been extended into sporadic preclinical Alzheimer's disease (AD).

DISCUSSION:

Plans for the next phase of the ADNI project include maintaining longitudinal follow-up of the normal and mild cognitive impairment cohorts, augmenting specific clinical cohorts, and incorporating novel computerized cognitive assessments and patient-reported outcomes. A major hypothesis is that AD represents a gradually progressive disease that can be identified precisely in its long presymptomatic phase, during which intervention with potentially disease-modifying agents may be most useful.

KEYWORDS:

Alzheimer's disease; Amyloid; Cognitive assessment

PMID:
26194309
PMCID:
PMC4643840
DOI:
10.1016/j.jalz.2015.05.005
[Indexed for MEDLINE]
Free PMC Article

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