Format

Send to

Choose Destination
Nat Immunol. 2015 Aug;16(8):802-9. doi: 10.1038/ni.3212.

Guarding the frontiers: the biology of type III interferons.

Author information

1
Francis Crick Institute, Mill Hill Laboratory, London, United Kingdom.
2
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

Abstract

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier tissues. IFN-λs thereby help to maintain healthy mucosal surfaces through immune protection, without the significant immune-related pathogenic risk associated with type I IFN responses. Type III IFNs also target the human liver, with dual effects: they induce an antiviral state in hepatocytes, but specific IFN-λ4 action impairs the clearance of hepatitis C virus and could influence inflammatory responses. This constitutes a paradox that has yet to be resolved.

PMID:
26194286
DOI:
10.1038/ni.3212
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center