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Expert Opin Drug Deliv. 2015;12(12):1943-53. doi: 10.1517/17425247.2015.1071352. Epub 2015 Jul 20.

'Smart' nanoparticles as drug delivery systems for applications in tumor therapy.

Author information

1
a 1 China Three Gorges University, Medical College , Yichang, Hubei 443002, China zhangyanqiong@ctgu.edu.cn ; wujiangfeng@ctgu.edu.cn.
2
b 2 China Three Gorges University, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy , Yichang, Hubei 443002, China.
3
c 3 Sichuan University, School of Chemical Engineering , Chengdu, Sichuan 610065, China.
4
d 4 Sichuan University, Collaborative Innovation Center for Biomaterials Science and Technology, State Key Laboratory of Polymer Materials Engineering , Chengdu, Sichuan 610065, China.

Abstract

INTRODUCTION:

In the therapy of clinical diseases such as cancer, it is important to deliver drugs directly to tumor sites in order to maximize local drug concentration and reduce side effects. This objective may be realized by using 'smart' nanoparticles (NPs) as drug delivery systems, because they enable dramatic conformational changes in response to specific physical/chemical stimuli from the diseased cells for targeted and controlled drug release.

AREAS COVERED:

In this review, we first briefly summarize the characteristics of 'smart' NPs as drug delivery systems in medical therapy, and then discuss their targeting transport, transmembrane and endosomal escape behaviors. Lastly, we focus on the applications of 'smart' NPs as drug delivery systems for tumor therapy.

EXPERT OPINION:

Biodegradable 'smart' NPs have the potential to achieve maximum efficacy and drug availability at the desired sites, and reduce the harmful side effects for healthy tissues in tumor therapy. It is necessary to select appropriate NPs and modify their characteristics according to treatment strategies of tumor therapy.

KEYWORDS:

controlled release; drug delivery; target delivery; tumor therapy; ‘smart’ nanoparticles

PMID:
26193970
DOI:
10.1517/17425247.2015.1071352
[Indexed for MEDLINE]

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