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Molecules. 2015 Jul 17;20(7):12992-3004. doi: 10.3390/molecules200712992.

Phytochemical properties and anti-proliferative activity of Olea europaea L. leaf extracts against pancreatic cancer cells.

Author information

1
Nutrition Food & Health Research Group, School of Environmental and Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia. chloe.d.goldsmith@uon.edu.au.
2
Nutrition Food & Health Research Group, School of Environmental and Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia. vanquan.vuong@newcastle.edu.au.
3
School of Biomedical Sciences and Pharmacy, University of Newcastle, Ourimbah, NSW 2258, Australia. elham.sadeqzadeh@newcastle.edu.au.
4
Faculty of Bioscience Engineering, Ghent University Global Campus, Incheon 406-840, Korea. costas.stathopoulos@ghent.ac.kr.
5
Nutrition Food & Health Research Group, School of Environmental and Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia. paul.roach@newcastle.edu.au.
6
Nutrition Food & Health Research Group, School of Environmental and Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia. c.scarlett@newcastle.edu.au.

Abstract

Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.

KEYWORDS:

Olea europaea L.; antioxidant activity; biophenols; oleuropein; olive leaf; pancreatic cancer; phenolic compounds; phytochemicals

PMID:
26193251
DOI:
10.3390/molecules200712992
[Indexed for MEDLINE]
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