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J Clin Hypertens (Greenwich). 2015 Nov;17(11):848-54. doi: 10.1111/jch.12622. Epub 2015 Jul 20.

Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic Patients.

Author information

1
Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada.
2
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
3
Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
4
Division of General Internal Medicine, McGill University, Montreal, QC, Canada.
5
Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.

Abstract

Thiazide diuretics (TDs) are a cost-effective first-line therapy for uncomplicated hypertension; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTaGENE project was used. Nondiabetic hypertensive participants on monotherapy for hypertension were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 hypertensive participants, 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, -1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated hypertension.

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PMID:
26191647
DOI:
10.1111/jch.12622
[Indexed for MEDLINE]
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