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World J Orthop. 2015 Jul 18;6(6):462-8. doi: 10.5312/wjo.v6.i6.462. eCollection 2015 Jul 18.

Use of bone marrow derived stem cells in trauma and orthopaedics: A review of current concepts.

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1
Philip S Pastides, Wasim S Khan, University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP, United Kingdom.

Abstract

There is a considerable amount of interest in the future role of bone marrow-derived stem cells (BMDSCs) and tissue engineering techniques to manage conditions within the musculoskeletal system. Repair of soft tissue and bone defects, in the early stages of injury, may lead to a reduction in progression of symptoms. Furthermore, troublesome soft tissue injuries that are notoriously fraught with problems either in healing or function, could be augmented with such techniques. The aim of this review paper is to look at the advances in such strategies to tackle these problems and assess how BMDSCs, with the aid of growth factors and scaffolds, are being used in vitro, animal and even human models to treat problems within the field of trauma and orthopaedics. There is plenty of evidence that the results are encouraging and thus gaining momentum toward their use in human studies.

KEYWORDS:

Bone marrow-derived stem cells; Growth factors; Orthopaedics; Scaffolds; Trauma

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